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The Yale Center for Thoracic Aortic Disease is one of the first officially designated aortic centers and one of the largest institutions in the world for clinical care of patients with aneurysms. The Center provides comprehensive management for patients with an aneurysm or aortic rupture. Since 2000, the volume of aneurysm patients has almost doubled, making the Center one of the most active facilities for treatment of aortic diseases in the country.
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Clinical research
The Center's investigative, clinical and scientific contributions to the study of thoracic aortic aneurysms are available in more than 75 publications on PubMed, the government resource for scientific medical publications.
John Elefteriades, MD and his research team, in collaboration with Dr. Olga Iakoubova and colleagues at Celera Genomics in California, are conducting advanced research into the molecular genetics of thoracic aortic aneurysm disease. They have developed a 31-RNA gene chip that is 85 percent accurate in determining — from a blood test only — whether a patient harbors a thoracic aneurysm. It is hoped that after further testing this gene chip test may become a widely applied screening test, like the PSA test for prostate cancer. The team has also recently identified DNA mutations that produce thoracic aortic aneurysms.
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